Recombinant人NHP2 protein (ab102027)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9NX24
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMTKIKADPDGPEAQAEACSGERTYQELLVN QNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMV LAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVK PHEEYQEAYDECLEEVQSLPLPL
    • 分子量19 kDa including tags
    • 氨基酸1 to 153
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab102027 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab102027 was purified using conventional chromatography.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • DKCB2
    • FLJ20479
    • H/ACA ribonucleoprotein complex subunit 2
    • NHP2
    • NHP2 like protein
    • NHP2 ribonucleoprotein
    • NHP2 ribonucleoprotein homolog
    • NHP2 ribonucleoprotein homolog (yeast) 1
    • NHP2, S. cerevisiae, homolog of
    • NHP2_HUMAN
    • NHP2P
    • NOLA2
    • Nucleolar protein family A member 2
    • Nucleolar protein family A member 2 (H/ACA small nucleolar RNPs)
    • snoRNP protein NHP2
    see all
  • 功能Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
  • 组织特异性Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver.
  • 疾病相关Dyskeratosis congenita, autosomal recessive, 2
  • 序列相似性Belongs to the ribosomal protein L7Ae family.
  • 发展阶段Transcript peaks at G1/S transition.
  • 细胞定位Nucleus > nucleolus. Nucleus > Cajal body. Also localized to Cajal bodies.
  • Information by UniProt

Recombinant Human NHP2 protein 图像

  • 15% SDS-PAGE analysis of ab102027 (3µg)

Recombinant Human NHP2 protein (ab102027)参考文献

ab102027 has not yet been referenced specifically in any publications.

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