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别名
- C80703
- cytoplasmic 3
- D8Ertd281e
- NF AT4
- NF ATc3
- NF-AT4
- NF-ATc3
- NFAC3_HUMAN
- NFATc3
- NFATx
- Nuclear factor of activated T cells, cytoplasmic 3
- nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
- Nuclear factor of activated T-cells
- T cell transcription factor NFAT4
- T-cell transcription factor NFAT4
see all
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功能
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.
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组织特异性
Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.
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序列相似性
Contains 1 RHD (Rel-like) domain.
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结构域
Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.
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翻译后修饰
Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin.
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细胞定位
Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
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Information by UniProt