The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
内毒素水平< 0.100 Eu/µg
补充说明Human Neurturin is fully biologically active when compared to standards.
Human Neurturin at a concentration of 100ng/ml will support the survival of 65% of newborn rat sympathetic neurons.
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
复溶Reconstitute in water to a concentration of 0.1mg/ml
功能Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
疾病相关Defects in NRTN are a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
序列相似性Belongs to the TGF-beta family. GDNF subfamily.