Recombinant人Neurotrophin 4 protein (ab9825)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列The active form of human NT-4 is a dimer formed by two identical 130 amino acid subunits that is held together by strong hydrophobic interactions: GVSETAPAS RRGELAVCDA VSGWVTDRRT AVDLRGREVE VLGEVPAAGG SPLRQ YFFETRCKADNAEEG GPGAGGGGCR GVDRRHWVSE CKAKQSYVRA L TADAQGRVG WRWIRIDTACVCTLLSRTGR A

技术指标

Our Abpromise guarantee covers the use of ab9825 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Functional Studies

    SDS-PAGE

  • 内毒素水平< 0.100 Eu/µg
  • 形式Lyophilised
  • 补充说明NT-4 is fully biologically active when compared to standards as determined by the dose-dependent induction of choline acetyl transferase activity in rat basa forebrain primary septal cell cultures. The expected ED50 for this effect is 20-50 ng/ml.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    n/a

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • GLC10
    • GLC1O
    • Neurotrophic factor 4
    • Neurotrophic factor 5
    • Neurotrophin 4/5
    • Neurotrophin 5
    • Neurotrophin 5 (neurotrophin 4/5)
    • Neurotrophin-4
    • Neurotrophin-5
    • Neutrophic factor 4
    • Neutrophic factor 5
    • NT 4
    • NT 4/5
    • NT 5
    • NT-4
    • NT-5
    • NT4
    • NT4/5
    • NT4P
    • NT5
    • NTF4
    • NTF4_HUMAN
    • NTF5
    see all
  • 功能Target-derived survival factor for peripheral sensory sympathetic neurons.
  • 组织特异性Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
  • 疾病相关Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O) [MIM:613100]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
  • 序列相似性Belongs to the NGF-beta family.
  • 细胞定位Secreted.
  • Information by UniProt

Recombinant human Neurotrophin 4 protein (ab9825)参考文献

ab9825 has not yet been referenced specifically in any publications.

Product Wall

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For ab9825, please use the instructions below for reconstituting the protein:

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For e...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"