重组人NeuroD1蛋白(ab152566)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDDLEAMNAEE DSLRNGGEEEDEDEDLEEEEEEEEEDDDQKPKRRGPKKKKMTKARLERFK LRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYI WALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQN QDMPPHLPTASASFPVHPYSYQSPGLPSPPYGTMDSSHVFHVKPPPHAYS AALEPFFESPLTDCTSPSFDGPLSPPLSINGNFSFKHEPSAEFEKNYAFT MHYPAATLAGAQSHGSIFSGTAAPRCEIPIDNIMSFDSHSHHERVMSAQL NAIFHD
    • 分子量
      66 kDa including tags
    • 氨基酸
      1 to 356

技术指标

Our Abpromise guarantee covers the use of ab152566 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • atonal
    • basic helix loop helix transcription factor
    • BETA 2
    • Beta cell E box transactivator 2
    • BETA2
    • BHF 1
    • BHF1
    • bHLHa3
    • class A basic helix loop helix protein 3
    • Class A basic helix-loop-helix protein 3
    • MODY 6
    • MODY6
    • NDF1_HUMAN
    • NeuroD
    • NeuroD1
    • Neurogenic differentiation 1
    • Neurogenic differentiation factor 1
    • neurogenic helix loop helix protein NEUROD
    • Neuronal differentiation 1
    see all
  • 功能
    Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.
  • 疾病相关
    Defects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • 序列相似性
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • 翻译后修饰
    Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.
  • 细胞定位
    Cytoplasm. Nucleus.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab152566 stained with Coomassie Blue.

文献

ab152566 has not yet been referenced specifically in any publications.

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