Recombinant人NELFe protein (ab104637)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMLVIPPGLSEEEEALQKKFNKLKKKKKALL ALKKQSSSSTTSQGGVKRSLSEQPVMDTATATEQAKQLVKSGAISAIKAE TKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSISADDDLQESSRRPQRK SLYESFVSSSDRLRELGPDGEEAEGPGAGDGPPRSFDWGYEERSGAHSSA SPPRSRSRDRSHERNRDRDRDRERDRDRDRDRDRERDRDRDRDRDRDRER DRDRERDRDRDREGPFRRSDSFPERRAPRKGNTLYVYGEDMTPTLLRGAF SPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVESVQLKVNIA RKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDVYKENLVDGF
    • 分子量
      45 kDa including tags
    • 氨基酸
      1 to 380
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab104637 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度
    > 85 % SDS-PAGE.
    ab104637 is purified using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0

常规信息

  • 别名
    • Major histocompatibility complex gene RD
    • Negative elongation factor E
    • Negative elongation factor polypeptide E
    • NELF e
    • NELF-E
    • Nelfe
    • NELFE_HUMAN
    • Nuclear protein
    • RD
    • RD protein
    • RD RNA binding protein
    • RDP
    • RNA-binding protein RD
    see all
  • 功能
    Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.
  • 组织特异性
    Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.
  • 序列相似性
    Belongs to the RRM NELF-E family.
    Contains 1 RRM (RNA recognition motif) domain.
  • 结构域
    The RRM domain interacts with RNA, and is essential for NELF complex function. It is however not required for the NELF complex formation.
  • 翻译后修饰
    Sumoylated.
  • 细胞定位
    Nucleus.
  • Information by UniProt

Recombinant Human NELFe protein 图像

  • 15% SDS-PAGE analysis of 3µg ab104637.
    Note: Real molecular weight on SDS-PAGE is shifted up compared to predicted molecular weight.

Recombinant Human NELFe protein (ab104637)参考文献

ab104637 has not yet been referenced specifically in any publications.

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