Recombinant人NEK11 protein (ab125544)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionQ8NG66
    • 种属Human
    • 分子量110 kDa including tags
    • 氨基酸1 to 645

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技术指标

Our Abpromise guarantee covers the use of ab125544 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The specific activity of ab125544 was determined to be 25 nmol/min/mg as per activity assay protocol.
  • 应用

    Western blot

    Functional Studies

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.
    Assessed by densitometry.
  • 形式Liquid
  • 补充说明

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.004% EGTA, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • 4932416N14Rik
    • FLJ23495
    • NEK11
    • NEK11_HUMAN
    • NEK11S/L
    • Never in mitosis A-related kinase 11
    • NIMA (never in mitosis gene a) related kinase 11
    • NIMA (never in mitosis gene a)- related kinase 11
    • NIMA related kinase 11L
    • NIMA related kinase 11S
    • NIMA-related kinase 11
    • NimA-related protein kinase 11
    • Serine/threonine-protein kinase Nek11
    see all
  • 功能Possible role in S-phase checkpoint mechanism.
  • 组织特异性Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
  • 序列相似性Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
    Contains 1 protein kinase domain.
  • 发展阶段Predominantly expressed at S/G2/M phase.
  • 翻译后修饰Phosphorylated.
  • 细胞定位Nucleus. Nucleus > nucleolus. Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S-arrested cells.
  • Information by UniProt

Recombinant human NEK11 protein 图像

  • SDS-PAGE analysis of ab125544.
  • The specific activity of ab125544 was determined to be 25nmol/min/mg.

Recombinant human NEK11 protein (ab125544)参考文献

ab125544 has not yet been referenced specifically in any publications.

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