- 来源Baculovirus infected Sf9 cells
- 分子量110 kDa including tags
- 氨基酸1 to 645
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 生物活性The specific activity of ab125544 was determined to be 25 nmol/min/mg as per activity assay protocol.
- 纯度> 90
Assessed by densitometry.
ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.004% EGTA, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- 功能Possible role in S-phase checkpoint mechanism.
- 组织特异性Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
- 序列相似性Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Contains 1 protein kinase domain.
- 发展阶段Predominantly expressed at S/G2/M phase.
- 细胞定位Nucleus. Nucleus > nucleolus. Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S-arrested cells.
Information by UniProt
Recombinant human NEK11 protein 图像
Recombinant human NEK11 protein (ab125544)参考文献
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"