Recombinant人NEK1 protein (ab116949)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ96PY6
    • 种属Human
    • 序列DVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSHLPPKN KNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQD
    • 分子量37 kDa including tags
    • 氨基酸976 to 1075

技术指标

Our Abpromise guarantee covers the use of ab116949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • DKFZp686D06121
    • DKFZp686K12169
    • kat
    • KIAA1901
    • MGC138800
    • MGC189817
    • NEK1
    • NEK1_HUMAN
    • Never in mitosis A-related kinase 1
    • Never in mitosis gene A-related kinase 1
    • NIMA (never in mitosis gene a)-related kinase 1
    • NIMA-related kinase 1
    • NimA-related protein kinase 1
    • NY-REN-55
    • OTTHUMP00000219432
    • OTTHUMP00000219433
    • OTTHUMP00000219434
    • OTTHUMP00000219435
    • Protein-serine/threonine kinase
    • Renal carcinoma antigen NY-REN-55
    • Serine/threonine-protein kinase Nek1
    • SRPS2
    • SRPS2A
    • SRTD6
    see all
  • 功能Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death.
  • 组织特异性High fetal expression in the brain and kidney.
  • 疾病相关Short-rib thoracic dysplasia 6 with or without polydactyly
  • 序列相似性Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
    Contains 1 protein kinase domain.
  • 细胞定位Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Associated with the pericentriolar material. Localizes to centrosome during interphase and mitosis (By similarity).
  • Information by UniProt

Recombinant Human NEK1 protein 图像

  • 12.5% SDS-PAGE showing ab116949 at approximately 36.63kDa stained with Coomassie Blue.

Recombinant Human NEK1 protein (ab116949)参考文献

ab116949 has not yet been referenced specifically in any publications.

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