Recombinant人NEK1 protein (ab116949)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      DVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSHLPPKN KNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQD
    • 分子量
      37 kDa including tags
    • 氨基酸
      976 to 1075

技术指标

Our Abpromise guarantee covers the use of ab116949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • DKFZp686D06121
    • DKFZp686K12169
    • kat
    • KIAA1901
    • MGC138800
    • MGC189817
    • NEK1
    • NEK1_HUMAN
    • Never in mitosis A-related kinase 1
    • Never in mitosis gene A-related kinase 1
    • NIMA (never in mitosis gene a)-related kinase 1
    • NIMA-related kinase 1
    • NimA-related protein kinase 1
    • NY-REN-55
    • OTTHUMP00000219432
    • OTTHUMP00000219433
    • OTTHUMP00000219434
    • OTTHUMP00000219435
    • Protein-serine/threonine kinase
    • Renal carcinoma antigen NY-REN-55
    • Serine/threonine-protein kinase Nek1
    • SRPS2
    • SRPS2A
    • SRTD6
    see all
  • 功能
    Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death.
  • 组织特异性
    High fetal expression in the brain and kidney.
  • 疾病相关
    Short-rib thoracic dysplasia 6 with or without polydactyly
  • 序列相似性
    Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
    Contains 1 protein kinase domain.
  • 细胞定位
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Associated with the pericentriolar material. Localizes to centrosome during interphase and mitosis (By similarity).
  • Information by UniProt

图片

  • 12.5% SDS-PAGE showing ab116949 at approximately 36.63kDa stained with Coomassie Blue.

文献

ab116949 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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