Recombinant人NEIL2 protein (ab124545)

概述

  • 产品名称Recombinant人NEIL2 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ969S2
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMGSHMPEGPLVRKFHHLVSPFVGQQVVKTG GSSKKLQPASLQSLWLQDTQVHGKKLFLRFDLDEEMGPPGSSPTPEPPQK EVQKEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGD AGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHFGGGGFLA FYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYF SGLGNIIKNEALYRAGIHPLSLGSVLSASRREVLVDHVVEFSTAWLQGKF QGRPQHTQVYQKEQCPAGHQVMKEAFGPEDGLQRLTWWCPQCQPQLSEEP EQCQFS
    • 分子量39 kDa including tags
    • 氨基酸1 to 332
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab124545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 85 % SDS-PAGE.
    ab124545 was purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

常规信息

  • 别名
    • DNA glycosylase/AP lyase Neil2
    • DNA-(apurinic or apyrimidinic site) lyase Neil2
    • Endonuclease 8-like 2
    • Endonuclease VIII-like 2
    • NEH2
    • Nei endonuclease VIII like 2
    • Nei endonuclease VIII like 2 (E. coli)
    • Nei homolog 2
    • Nei-like 2
    • Nei-like protein 2
    • NEI2
    • NEIL2
    • NEIL2_HUMAN
    see all
  • 功能Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  • 组织特异性Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver.
  • 序列相似性Belongs to the FPG family.
    Contains 1 FPG-type zinc finger.
  • 结构域The zinc-finger domain is important for DNA binding.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human NEIL2 protein 图像

  • 15% SDS-PAGE analysis of 3 µg ab124545.

Recombinant Human NEIL2 protein (ab124545)参考文献

ab124545 has not yet been referenced specifically in any publications.

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