Recombinant人NEIL1 protein (ab123204)

概述

  • 产品名称Recombinant人NEIL1 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ96FI4
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MPEGPELHLA SQFVNEACRA LVFGGCVEKS SVSRNPEVPF ESSAYRISAS ARGKELRLIL SPLPGAQPQQ EPLALVFRFG MSGSFQLVPR EELPRHAHLR FYTAPPGPRL ALCFVDIRRF GRWDLGGKWQ PGRGPCVLQE YQQFRENVLR NLADKAFDRP ICEALLDQRF FNGIGNYLRA EILYRLKIPP FEKARSVLEA LQQHRPSPEL TLSQKIRTKL QNPDLLELCH SVPKEVVQLG GKGYGSESGE EDFAAFRAWL RCYGMPGMSS LQDRHGRTIW FQGDPGPLAP KGRKSRKKKS KATQLSPEDR VEDALPPSKA PSRTRRAKRD LPKRTATQRP EGTSLQQDPE APTVPKKGRR KGRQAASGHC RPRKVKADIP SLEPEGTSAS
    • 分子量46 kDa including tags
    • 氨基酸1 to 390
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab123204 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab123204 is purified using conventional chromatography.
  • 形式Liquid
  • 补充说明EC=3.2.2.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.002% PMSF, 0.02% DTT, 0.32% Tris HCl, 20% Glycerol, 0.58% Sodium chloride

常规信息

  • 别名
    • DNA (apurinic or apyrimidinic site) lyase Neil1
    • DNA glycosylase/AP lyase Neil 1
    • DNA glycosylase/AP lyase Neil1
    • DNA-(apurinic or apyrimidinic site) lyase Neil1
    • Endonuclease 8 like 1
    • Endonuclease 8-like 1
    • Endonuclease VIII
    • Endonuclease VIII like 1
    • Endonuclease VIII-like 1
    • FLJ22402
    • FPG1
    • hFPG1
    • NEH 1
    • NEH1
    • NEI 1
    • Nei endonuclease VIII like 1
    • Nei endonuclease VIII like 1 (E. coli)
    • Nei homolog 1
    • Nei like 1
    • Nei like protein 1
    • Nei-like protein 1
    • NEI1
    • NEIL 1
    • Neil1
    • NEIL1_HUMAN
    see all
  • 功能Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.
  • 组织特异性Ubiquitous.
  • 序列相似性Belongs to the FPG family.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human NEIL1 protein 图像

  • 15% SDS-PAGE analysis of ab123204 (3ug)

Recombinant Human NEIL1 protein (ab123204)参考文献

ab123204 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"