The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab116433 was purified by proprietary chromatographic techniques and filter sterilized.
ab116433 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
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Shipped at 4°C. Please see notes section.
pH: 8.00 Constituents: 0.32% Tris HCl, 30% Glycerol
CI 18 kDa
Complex I 18 kDa
Complex I AQDQ
Complex I-18 kDa
mitochondrial respiratory chain complex I (18 KD subunit)
NADH coenzyme Q reductase
NADH dehydrogenase (ubiquinone) Fe S protein 4 18kDa
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4
NADH ubiquinone oxidoreductase 18 kDa subunit
NADH-ubiquinone oxidoreductase 18 kDa subunit
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Defects in NDUFS4 are a cause of mitochondrial complex I deficiency (MT-C1D) [MIM:252010]. A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease.