Recombinant人NDST1 protein (ab116875)

概述

  • 产品名称
    Recombinant人NDST1 protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      LYGWKRGLEPSADAPEPDCGDPPPVAPSRLLPLKPVQAATPSRTDPLVLV FVESLYSQLGQEVVAILESSRFKYRTEIAPGKGDMPTLTDKGRGRFALI
    • 分子量
      37 kDa including tags
    • 氨基酸
      38 to 136

技术指标

Our Abpromise guarantee covers the use of ab116875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • [Heparan sulfate]-glucosamine N-sulfotransferase 1
    • Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
    • Glucosaminyl N-deacetylase/N-sulfotransferase 1
    • Heparan sulfate N-deacetylase 1
    • Heparan sulfate N-sulfotransferase 1
    • HSNST 1
    • HSST
    • HSST1
    • N-heparan sulfate sulfotransferase 1
    • N-HSST 1
    • NDST-1
    • Ndst1
    • NDST1_HUMAN
    see all
  • 功能
    Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response.
  • 组织特异性
    Widely expressed. Expression is most abundant in heart, liver and pancreas.
  • 通路
    Glycan metabolism; heparan sulfate biosynthesis.
    Glycan metabolism; heparin biosynthesis.
  • 序列相似性
    Belongs to the sulfotransferase 1 family. NDST subfamily.
  • 细胞定位
    Golgi apparatus membrane.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE of ab116875 at approximately 36.52kDa, stained with Coomassie Blue.

文献

ab116875 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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