Recombinant人NDE1 protein (ab106891)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMEDSGKTFSSEEEEANYWKDLAMTYKQRAE NTQEELREFQEGSREYEAELETQLQQIETRNRDLLSENNRLRMELETIKE KFEVQHSEGYRQISALEDDLAQTKAIKDQLQKYIRELEQANDDLERAKRA TIMSLEDFEQRLNQAIERNAFLESELDEKENLLESVQRLKDEARDLRQEL AVQQKQEKPRTPMPSSVEAERTDTAVQATGSVPSTPIAHRGPSSSLNTPG SFRRGLDDSTGGTPLTPAARISALNIVGDLLRKVGALESKLASCRNLVYD QSPNRTGGPASGRSSKNRDGGERRPSSTSVPLGDKGLDTSCRWLSKSTTR SSSSC
    • 分子量
      40 kDa including tags
    • 氨基酸
      1 to 335
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab106891 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 质谱法
    MALDI-TOF
  • 纯度
    > 85 % SDS-PAGE.
    ab106891 is purified using conventional chromatography techniques. Purity is > 85 % by SDS-PAGE.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 20% Glycerol, 0.08% DTT, 1.17% Sodium chloride

常规信息

  • 别名
    • FLJ20101
    • HOM TES 87
    • LIS1 interacting protein NUDE1
    • LIS1 interacting protein NUDE1 rat homolog
    • LIS4
    • NDE 1
    • NDE1
    • NDE1_HUMAN
    • Nuclear distribution gene E homolog 1
    • Nuclear distribution protein nudE homolog 1
    • NudE
    • NUDE 1
    • NudE nuclear distribution gene E homolog 1
    • NudE nuclear distribution gene E homolog 1 (A. nidulans)
    • NUDE1
    see all
  • 功能
    Required for centrosome duplication. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex (By similarity). Required for formation and function of the mitotic spindle.
  • 序列相似性
    Belongs to the nudE family.
  • 翻译后修饰
    Phosphorylated in mitosis.
  • 细胞定位
    Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > spindle. Cleavage furrow. Localizes to the interphase centrosome and to the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis.
  • Information by UniProt

Recombinant Human NDE1 protein 图像

  • 15% SDS-PAGE showing ab106891 at approximately 39.9kDa (3µg).

Recombinant Human NDE1 protein (ab106891)参考文献

ab106891 has not yet been referenced specifically in any publications.

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