Recombinant人NCS1 protein (ab116417)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP62166
    • 种属Human
    • 序列MGKSNSKLKP EVVEELTRKT YFTEKEVQQW YKGFIKDCPS GQLDAAGFQK IYKQFFPFGD PTKFATFVFN VFDENKDGRI EFSEFIQALS VTSRGTLDEK LRWAFKLYDL DNDGYITRNE MLDIVDAIYQ MVGNTVELPE EENTPEKRVD RIFAMMDKNA DGKLTLQEFQ EGSKADPSIV QALSLYDGLV LEHHHHHH
    • 分子量23 kDa including tags
    • 氨基酸1 to 190
    • 标签His tag C-Terminus

技术指标

Our Abpromise guarantee covers the use of ab116417 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    Purified by proprietary chromatographic techniques. Sterile Filtered clear colorless solution.
  • 形式Liquid
  • 补充说明Although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days. Please avoid freeze-thaw cycles.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol

常规信息

  • 别名
    • 9430075O15Rik
    • A730032G13Rik
    • AI836659
    • DKFZp761L1223
    • FLUP
    • FREQ
    • Frequenin
    • Frequenin homolog
    • Frequenin homolog (Drosophila)
    • Frequenin like protein
    • Frequenin, Drosophila, homolog of
    • Frequenin-like protein
    • Frequenin-like ubiquitous protein
    • Mfreq
    • NCS 1
    • NCS-1
    • ncs1
    • NCS1_HUMAN
    • Neuronal calcium sensor 1
    • Neuronal Calicum Sensor 1
    see all
  • 功能Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.
  • 序列相似性Belongs to the recoverin family.
    Contains 4 EF-hand domains.
  • 细胞定位Golgi apparatus > Golgi stack membrane. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cytoplasm > perinuclear region. Cell membrane. Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.
  • Information by UniProt

Recombinant Human NCS1 protein (ab116417)参考文献

ab116417 has not yet been referenced specifically in any publications.

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