Recombinant人Nck protein (ab85711)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab85711 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: 150mM Imidazole
    Constituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 2mM DTT, 0.1mM PMSF, pH 7.0

常规信息

  • 别名
    • Cytoplasmic protein NCK1
    • Melanoma Nck protein
    • MGC12668
    • NCK
    • NCK 1
    • NCK adaptor protein 1
    • NCK alpha
    • NCK tyrosine kinase
    • Nck-1
    • NCK1
    • NCK1_HUMAN
    • NCKalpha
    • Non catalytic region of tyrosine kinase
    • SH2/SH3 adaptor protein NCK alpha
    • SH2/SH3 adaptor protein NCK-alpha
    see all
  • 功能Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2.
  • 序列相似性Contains 1 SH2 domain.
    Contains 3 SH3 domains.
  • 翻译后修饰Phosphorylated on Ser and Tyr residues.
  • 细胞定位Cytoplasm. Endoplasmic reticulum. Nucleus. Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.
  • Information by UniProt

Recombinant Human Nck protein 图像

  • SDS-PAGE showing ab85711 at approximately 48kDa.

Recombinant Human Nck protein (ab85711)参考文献

ab85711 has not yet been referenced specifically in any publications.

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