Recombinant人NADPH oxidase 4 protein (ab112414)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ9NPH5
    • 种属Human
    • 序列LHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKL LFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
    • 分子量37 kDa including tags
    • 氨基酸479 to 578

技术指标

Our Abpromise guarantee covers the use of ab112414 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Checker: see comments on ab112406.
  • 应用

    ELISA

    Peptide Array

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Best used within three months from the date of receipt Checker: see comments on ab112406.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced.

常规信息

  • 别名
    • Kidney oxidase-1
    • Kidney superoxide-producing NADPH oxidase
    • KOX
    • KOX 1
    • Kox-1
    • NADPH
    • NADPH oxidase 4
    • Nox4
    • NOX4_HUMAN
    • Renal NAD(P)H-oxidase
    • RENOX
    see all
  • 功能Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity.
  • 组织特异性Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells.
  • 序列相似性Contains 1 FAD-binding FR-type domain.
    Contains 1 ferric oxidoreductase domain.
  • 发展阶段Expressed in fetal kidney and fetal liver.
  • 翻译后修饰Isoform 3 and isoform 4 are N-glycosylated. Isoform 4 glycosylation is required for its proper function.
  • 细胞定位Endoplasmic reticulum membrane. Cell membrane. Cell junction > focal adhesion. Nucleus. May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus.
  • Information by UniProt

Recombinant Human NADPH oxidase 4 protein 图像

  • 12% SDS-PAGE image showing ab112414 at approx 36.63kDa

Recombinant Human NADPH oxidase 4 protein (ab112414)参考文献

ab112414 has not yet been referenced specifically in any publications.

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