Recombinant人NACA1 protein (ab113865)

概述

  • 产品名称Recombinant人NACA1 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ13765
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMPGEATETVPATEQELPQPQAETGSGTESD SDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAM SKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIED LSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVKD IELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM
    • 分子量26 kDa including tags
    • 氨基酸1 to 215
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 95 % SDS-PAGE.
    ab113865 was purified by using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定���和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol, 0.02% DTT, 0.88% Sodium chloride

常规信息

  • 别名
    • Alpha NAC
    • Alpha-NAC
    • Hom s 2.02
    • HSD48
    • MGC117224
    • NAC-alpha
    • naca
    • NACA/1.9.2
    • NACA_HUMAN
    • NACA1
    • Nascent polypeptide associated complex alpha polypeptide
    • Nascent polypeptide associated complex alpha subunit
    • Nascent polypeptide associated complex subunit alpha
    • Nascent polypeptide-associated complex subunit alpha
    see all
  • 功能Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.
  • 组织特异性Ubiquitously expressed.
  • 序列相似性Belongs to the NAC-alpha family.
    Contains 1 NAC-A/B (NAC-alpha/beta) domain.
    Contains 1 UBA domain.
  • 翻译后修饰Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization. Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm. Nucleus. Predominantly cytoplasmic. Also found in nucleus.
  • Information by UniProt

Recombinant Human NACA1 protein 图像

  • ab113865 at 3 µg analysed by 15% SDS-PAGE.

Recombinant Human NACA1 protein (ab113865)参考文献

ab113865 has not yet been referenced specifically in any publications.

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