Recombinant人n-Myc protein (ab114325)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIW KKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLG GLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSP GAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKR EPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHK ALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTIT VRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKI KSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSS FLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQAR QQQLLKKIEHARTC
    • 分子量
      77 kDa
    • 氨基酸
      1 to 464
    • 标签
      GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab114325 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • bHLHe37
    • Class E basic helix-loop-helix protein 37
    • MODED
    • mycn
    • MYCN_HUMAN
    • N myc
    • N myc proto oncogene protein
    • N-myc proto-oncogene protein
    • Neuroblastoma derived v myc avian myelocytomatosis viral related oncogene
    • Neuroblastoma MYC oncogene
    • NMYC
    • NMYC proto oncogene protein
    • ODED
    • Oncogene NMYC
    • pp65/67
    • V myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
    • v myc avian myelocytomatosis viral related oncogene neuroblastoma derived
    • v myc myelocytomatosis viral related oncogene neuroblastoma derived
    see all
  • 功能
    May function as a transcription factor.
  • 疾病相关
    Note=Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.
    Defects in MYCN are the cause of microcephaly-oculo-digito-esophageal-duodenal syndrome (MODED) [MIM:164280]; also known as oculodigitoesophagoduodenal syndrome (ODED). Microcephaly-oculo-digito-esophageal-duodenal syndrome is characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability and limb malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.
    Defects in MYCN are the cause of microcephaly and digital abnormalities with normal intelligence (MCPHDANI) [MIM:602585].
  • 序列相似性
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • 发展阶段
    Expressed during fetal development.
  • 细胞定位
    Nucleus.
  • Information by UniProt

图片

  • SDS-PAGE analysis of ab114325 on a 12.5% gel stained with Coomassie Blue.

文献

ab114325 has not yet been referenced specifically in any publications.

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