Recombinant人Myocilin protein (ab116838)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ99972
    • 种属Human
    • 序列MRFFCARCCSFGPEMPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYT FSVASPNESSCPEQSQAMSVIHNLQRDSSTQRLDLEATKARLSSLESLLH QLTLDQAARPQETQEGLQRELGTLRRERDQLETQTRELETAYSNLLRDKS VLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGSR EVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGEGDTGCGELVW VGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFE YDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELN TETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGA IVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVN FAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIK LSKM
    • 分子量82 kDa including tags
    • 氨基酸1 to 504

技术指标

Our Abpromise guarantee covers the use of ab116838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • GLC1A
    • GPOA
    • JOAG
    • JOAG1
    • Mutated trabecular meshwork-induced glucocorticoid response protein
    • MYOC
    • MYOC_HUMAN
    • Myocilin
    • Myocilin, trabecular meshwork inducible glucocorticoid
    • TIGR
    • Trabecular meshwork induced glucocorticoid response protein
    • Trabecular meshwork-induced glucocorticoid response protein
    see all
  • 功能May participate in the obstruction of fluid outflow in the trabecular meshwork.
  • 组织特异性Expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma.
  • 疾病相关Defects in MYOC are the cause of primary open angle glaucoma type 1A (GLC1A) [MIM:137750]. Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
    Defects in MYOC may also contribute to primary congenital glaucoma type 3A (GLC3A) [MIM:231300]. Defects in MYOC may contribute to this phenotype via digenic inheritance. GLC3A is an autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early choldhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
  • 序列相似性Contains 1 olfactomedin-like domain.
  • 翻译后修饰Different isoforms may arise by post-translational modifications.
    Glycosylated.
    Palmitoylated.
  • 细胞定位Rough endoplasmic reticulum. Secreted. Cell projection > cilium. Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum. Also secreted.
  • Information by UniProt

Recombinant Human Myocilin protein 图像

  • 12.5% SDS-PAGE stained with Coomassie Blue showing ab116838 at approximately 81.55 kDa.

Recombinant Human Myocilin protein (ab116838)参考文献

ab116838 has not yet been referenced specifically in any publications.

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