Recombinant人MYLK2 protein (ab84800)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab84800 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Specific activity: 270nmol/min/mg.
  • 应用

    Western blot

    Functional Studies

  • 形式Liquid
  • 补充说明

    ab60014 (Mouse MYL9 full length protein) can be utilized as a substrate for assessing Kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Preservative: 1.02% Imidazole
    Constituents: 0.00174% PMSF, 0.82% Sodium phosphate, 0.00308% DTT, 25% Glycerol, 1.74% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • KMLC
    • MLCK
    • MLCK, skeletal/cardiac
    • MLCK2
    • MYLK 2
    • MYLK2
    • MYLK2_HUMAN
    • Myosin light chain kinase 2
    • Myosin light chain kinase 2 skeletal muscle
    • Myosin light chain kinase 2 skeletal/cardiac muscle
    • MYOSIN LIGHT POLYPEPTIDE KINASE
    • Myosin light polypeptide kinase, skeletal/cardiac
    • Skeletal muscle myosin light chain kinase
    • Skeletal myosin light chain kinase
    • skeletal/cardiac muscle
    • skMLCK
    see all
  • 功能Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
  • 组织特异性Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.
  • 疾病相关Defects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 序列相似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • 细胞定位Cytoplasm. Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
  • Information by UniProt

Recombinant human MYLK2 protein 图像

  • Specific activity of ab84800
  • SDS page analysis of ab84800

Recombinant human MYLK2 protein (ab84800)参考文献

ab84800 has not yet been referenced specifically in any publications.

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