Recombinant人Myeloid leukemia factor 1 protein (ab40569)

概述

  • 产品名称Recombinant人Myeloid leukemia factor 1 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human

相关产品

技术指标

Our Abpromise guarantee covers the use of ab40569 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: 0.002% Sodium Azide
    Constituents: 0.1% Triton X-100, 10mM Tris, pH 8.0

常规信息

  • 别名
    • Hls7
    • MLF1
    • MLF1_HUMAN
    • Myelodysplasia myeloid leukemia factor 1
    • Myelodysplasia-myeloid leukemia factor 1
    • Myeloid leukemia factor 1
    • myeloid leukemia factor 1 variant 1
    • myeloid leukemia factor 1 variant 2
    • myeloid leukemia factor 1 variant 3
    see all
  • 功能Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
  • 组织特异性Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
  • 疾病相关Note=A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM.
  • 序列相似性Belongs to the MLF family.
  • 翻译后修饰Phosphorylation is required for binding to YWHAZ.
  • 细胞定位Cytoplasm. Nucleus. In non-hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM.
  • Information by UniProt

Recombinant Human Myeloid leukemia factor 1 protein 图像

  • Analysis of Myeloid leukemia factor 1 Recombinant Protein.
    4-20% SDS gradient gel. Coomassie blue staining.

Recombinant Human Myeloid leukemia factor 1 protein (ab40569)参考文献

ab40569 has not yet been referenced specifically in any publications.

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