Recombinant人Myeloid leukemia factor 1 protein (ab40569)

概述

  • 产品名称
    Recombinant人Myeloid leukemia factor 1 protein
  • 蛋白长度
    Full length protein

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human

相关产品

技术指标

Our Abpromise guarantee covers the use of ab40569 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 纯度
    > 95 % SDS-PAGE.

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: 0.002% Sodium Azide
    Constituents: 0.1% Triton X-100, 10mM Tris, pH 8.0

常规信息

  • 别名
    • Hls7
    • MLF1
    • MLF1_HUMAN
    • Myelodysplasia myeloid leukemia factor 1
    • Myelodysplasia-myeloid leukemia factor 1
    • Myeloid leukemia factor 1
    • myeloid leukemia factor 1 variant 1
    • myeloid leukemia factor 1 variant 2
    • myeloid leukemia factor 1 variant 3
    see all
  • 功能
    Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
  • 组织特异性
    Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
  • 疾病相关
    Note=A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM.
  • 序列相似性
    Belongs to the MLF family.
  • 翻译后修饰
    Phosphorylation is required for binding to YWHAZ.
  • 细胞定位
    Cytoplasm. Nucleus. In non-hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM.
  • Information by UniProt

图片

  • Analysis of Myeloid leukemia factor 1 Recombinant Protein.
    4-20% SDS gradient gel. Coomassie blue staining.

文献

ab40569 has not yet been referenced specifically in any publications.

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