Recombinant人MUSK protein (ab71693)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionO15146
    • 种属Human
    • 分子量63 kDa
    • 标签GST tag N-Terminus
    • 额外的序列信息Recombinant fragment from human MUSK, cytoplasmic domain, amino acids 519-end.

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技术指标

Our Abpromise guarantee covers the use of ab71693 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性

    Specific activity is 6.7 nmol/min/mg.

  • 应用

    SDS-PAGE

    Functional Studies

  • 形式Liquid
  • 补充说明

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • MDK 4
    • MDK4
    • MGC126323
    • MGC126324
    • Muscle
    • Muscle skeletal receptor tyrosine kinase
    • Muscle skeletal receptor tyrosine protein kinase
    • Muscle specific kinase receptor
    • Muscle specific tyrosine kinase receptor
    • Muscle specific tyrosine protein kinase receptor
    • Muscle-specific kinase receptor
    • Muscle-specific tyrosine-protein kinase receptor
    • MuSK
    • MUSK_HUMAN
    • Neural fold somite kinase 1
    • Neural fold somite kinase 2
    • Neural fold somite kinase 3
    • Neural fold somite kinase1
    • Neural fold somite kinase2
    • Neural fold somite kinase3
    • Nsk 1
    • Nsk 2
    • Nsk 3
    • Nsk1
    • Nsk2
    • Nsk3
    • Receptor tyrosine kinase MuSK
    • Skeletal muscle receptor tyrosine kinase
    • skeletal receptor tyrosine-protein kinase
    see all
  • 功能Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization.
  • 疾病相关Defects in MUSK is a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (CMS-ACHRD) [MIM:608931]. A post-synaptic congenital myasthenic syndrome. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance. Note=MUSK mutations lead to decreased agrin-dependent AChR aggregation, a critical step in the formation of the neuromuscular junction.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family.
    Contains 1 FZ (frizzled) domain.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • 翻译后修饰Ubiquitinated by PDZRN3. Ubiquitination promotes endocytosis and lysosomal degradation.
  • 细胞定位Membrane.
  • Information by UniProt

Recombinant human MUSK protein 图像

Recombinant human MUSK protein (ab71693)参考文献

ab71693 has not yet been referenced specifically in any publications.

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