This product is an active protein and may elicit a biological response in vivo, handle with caution.
E3 ubiquitin-protein ligase TRIM63
Iris RING finger protein
Muscle specific ring finger protein 1
Muscle specific ring finger protein 2
Muscle-specific RING finger protein 1
RING finger protein 28
Striated muscle RING zinc finger protein
Tripartite motif containing 63
tripartite motif containing 63, E3 ubiquitin protein ligase
Tripartite motif containing protein 63
Tripartite motif-containing protein 63
Ubiquitin ligase TRIM63
功能E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
组织特异性Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.
通路Protein modification; protein ubiquitination.
序列相似性Contains 1 B box-type zinc finger. Contains 1 COS domain. Contains 1 RING-type zinc finger.
发展阶段Expressed throughout all developmental stages.
结构域The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity.
细胞定位Cytoplasm. Nucleus. Localizes to the M- and Z-lines in skeletal muscle. Colocalizes with TNNI3 in myocytes.