Recombinant人Munc18-1 protein (ab114603)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP61764
    • 种属Human
    • 序列VYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRA AKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPI
    • 分子量36 kDa including tags
    • 氨基酸74 to 168

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技术指标

Our Abpromise guarantee covers the use of ab114603 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

    SDS-PAGE

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • FLJ37475
    • Munc 18 1
    • Munc 18a
    • MUNC18 1
    • N-Sec1
    • Neuronal SEC1
    • NSec1
    • p67
    • Protein unc-18 homolog 1
    • Protein unc-18 homolog A
    • Rb sec1
    • RBSEC1
    • STXB1_HUMAN
    • STXBP1
    • Syntaxin binding protein 1
    • Syntaxin-binding protein 1
    • Unc 18 homolog
    • Unc 18A
    • Unc-18A
    • UNC18
    • Unc18 1
    • Unc18-1
    see all
  • 功能May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
  • 组织特异性Brain and spinal cord. Highly enriched in axons.
  • 疾病相关Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.
  • 序列相似性Belongs to the STXBP/unc-18/SEC1 family.
  • 细胞定位Cytoplasm. Membrane.
  • Information by UniProt

Recombinant Human Munc18-1 protein 图像

  • ab114603 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human Munc18-1 protein (ab114603)参考文献

ab114603 has not yet been referenced specifically in any publications.

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