Recombinant人MUM1 protein (ab83638)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 氨基酸144 to 451

技术指标

Our Abpromise guarantee covers the use of ab83638 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5

常规信息

  • 别名
    • Interferon regulatory factor 4
    • IRF 4
    • IRF-4
    • Irf4
    • IRF4_HUMAN
    • LSIRF
    • Lymphocyte specific interferon regulatory factor
    • Lymphocyte specific IRF
    • Lymphocyte-specific interferon regulatory factor
    • Multiple myeloma oncogene 1
    • MUM 1
    • MUM1
    • NF EM5
    • NF-EM5
    • NFEM5
    • PU.1 interaction partner
    • Sfpi1/PU.1 interaction partner
    • Transcriptional activator PIP
    see all
  • 功能Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.
  • 组织特异性Lymphoid cells.
  • 疾病相关Defects in IRF4 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IRF4 is found in multiple myeloma. Translocation t(6;14)(p25;q32) with the IgH locus.
  • 序列相似性Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human MUM1 protein (ab83638)参考文献

ab83638 has not yet been referenced specifically in any publications.

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