Recombinant人MTH1 protein (ab99390)

概述

  • 产品名称Recombinant人MTH1 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP36639
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMGASRLYTLVLVLQPQRVLLGMKKRGFGAG RWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPEL MDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQK KKFHGYFKFQGQDTILDYTLREVDTV
    • 分子量20 kDa including tags
    • 氨基酸1 to 156
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab99390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 95 % SDS-PAGE.
    ab99390 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 2mM DTT, 100mM Sodium chloride, pH 8.0

常规信息

  • 别名
    • 2-hydroxy-dATP diphosphatase
    • 7
    • 7 8 dihydro 8 oxoguanine triphosphatase
    • 8 oxo 7 8 dihydrodeoxyguanosine triphosphatase
    • 8 oxo 7 8 dihydroguanosine triphosphatase
    • 8 oxo dGTPase
    • 8-dihydro-8-oxoguanine triphosphatase
    • 8-oxo-dGTPase
    • 8ODP_HUMAN
    • MTH 1
    • MTH1
    • MutT human homolog 1
    • Nucleoside diphosphate linked moiety X motif 1
    • Nucleoside diphosphate linked moiety X type motif 1
    • Nucleoside diphosphate-linked moiety X motif 1
    • Nudix (nucleoside diphosphate linked moiety X) type motif 1
    • Nudix hydrolase 1
    • Nudix motif 1
    • Nudix type motif 1
    • NUDT 1
    • Nudt1
    see all
  • 功能Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
  • 组织特异性Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
  • 序列相似性Belongs to the Nudix hydrolase family.
    Contains 1 nudix hydrolase domain.
  • 发展阶段In peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.
  • 翻译后修饰The N-terminus is blocked.
  • 细胞定位Cytoplasm. Mitochondrion matrix and Cytoplasm. Mitochondrion matrix. Nucleus. Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
  • Information by UniProt

Recombinant Human MTH1 protein 图像

  • 15% SDS-PAGE analysis of 3µg ab99390.

Recombinant Human MTH1 protein (ab99390)参考文献

ab99390 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"