Nucleoside diphosphate linked moiety X type motif 1
Nucleoside diphosphate-linked moiety X motif 1
Nudix (nucleoside diphosphate linked moiety X) type motif 1
Nudix hydrolase 1
Nudix motif 1
Nudix type motif 1
功能Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
组织特异性Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
序列相似性Belongs to the Nudix hydrolase family. Contains 1 nudix hydrolase domain.
发展阶段In peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.
翻译后修饰The N-terminus is blocked.
细胞定位Cytoplasm. Mitochondrion matrix and Cytoplasm. Mitochondrion matrix. Nucleus. Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.