Recombinant人MRP6 protein (ab114729)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionO95255
    • 种属Human
    • 序列IAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAG RRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRV
    • 分子量37 kDa including tags
    • 氨基酸831 to 930

相关产品

技术指标

Our Abpromise guarantee covers the use of ab114729 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • ABC34
    • Abcc6
    • Anthracycline resistance-associated protein
    • ARA
    • ATP binding cassette sub family C (CFTR/MRP) member 6
    • ATP binding cassette sub family C member 6
    • ATP-binding cassette sub-family C member 6
    • EST349056
    • MLP1
    • MOAT E
    • MOAT-E
    • MOATE
    • MRP 6
    • MRP6
    • MRP6_HUMAN
    • Multi-specific organic anion transporter E
    • Multidrug resistance associated protein 6
    • Multidrug resistance-associated protein 6
    • multispecific organic anion transporter E
    • PXE
    • PXE1
    • URG7
    • URG7 protein
    see all
  • 功能May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).
  • 组织特异性Expressed in kidney and liver. Very low expression in other tissues.
  • 疾病相关Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE) [MIM:264800]. PXE is a disorder characterized by calcification of elastic fibers in skin, arteries and retina that results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype (autosomal dominant PXE).
  • 序列相似性Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • 细胞定位Membrane. Localized to the basolateral membrane.
  • Information by UniProt

Recombinant Human MRP6 protein 图像

  • 12.5% SDS-PAGE showing ab114729 at approximately 36.63kDa.
    Stained with Coomassie Blue.

Recombinant Human MRP6 protein (ab114729)参考文献

ab114729 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114729.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"