Recombinant人MRP2 protein (ab112272)

概述

  • 产品名称Recombinant人MRP2 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ92887
    • 种属Human
    • 序列LKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEK SSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKA
    • 分子量37 kDa including tags
    • 氨基酸214 to 313
    • 标签GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab112272 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性useful for Antibody Production and Protein Array
  • 应用

    ELISA

    Western blot

    SDS-PAGE

  • 形式Liquid
  • 补充说明Best use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

常规信息

  • 别名
    • ABC30
    • abcC2
    • ATP binding cassette sub family C (CFTR/MRP) member 2
    • ATP binding cassette subfamily C member 2
    • ATP-binding cassette sub-family C member 2
    • Canalicular multidrug resistance protein
    • Canalicular multispecific organic anion transporter 1
    • CMOAT
    • CMOAT1
    • cMRP
    • DJS
    • KIAA1010
    • MRP 2
    • MRP2_HUMAN
    • Multidrug resistance associated protein 2
    • Multidrug resistance-associated protein 2
    see all
  • 功能Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
  • 组织特异性Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.
  • 疾病相关Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
  • 序列相似性Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • 细胞定位Membrane.
  • Information by UniProt

Recombinant Human MRP2 protein 图像

  • 12.5% SDS-PAGE Stained with Coomassie Blue

Recombinant Human MRP2 protein (ab112272)参考文献

ab112272 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"