Recombinant人Mre11 protein (ab114277)

概述

  • 产品名称Recombinant人Mre11 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ9BS79
    • 种属Human
    • 序列MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQEN EVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVN FGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFV NHFGRSMSVEKIDISPVLLQKGRTKIALYGLGSIPDERLYRMFVNKKVTM LRPKED
    • 分子量49 kDa including tags
    • 氨基酸1 to 206

技术指标

Our Abpromise guarantee covers the use of ab114277 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • AT like disease
    • Ataxia telangiectasia disorder like
    • ATLD
    • DNA recombination and repair protein
    • Double strand break repair protein MRE11A
    • Double-strand break repair protein MRE11A
    • endo/exonuclease Mre11
    • HNGS1
    • meiotic recombination (S. cerevisiae) 11 homolog A
    • Meiotic recombination 11 homolog 1
    • Meiotic recombination 11 homolog A
    • meiotic recombination 11 homolog A (S. cerevisiae)
    • MmMRE11A
    • Mre 11
    • MRE 11a
    • MRE 11b
    • MRE11 homolog 1
    • MRE11 homolog A
    • MRE11 meiotic recombination 11 homolog A
    • MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
    • MRE11_HUMAN
    • MRE11A
    • MRE11b
    • OTTHUMP00000236830
    • OTTHUMP00000236831
    • OTTHUMP00000236832
    • OTTHUMP00000236833
    see all
  • 功能Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
  • 疾病相关Defects in MRE11A are a cause of ataxia telangiectasia-like disorder (ATLD) [MIM:604391]. ATLD is a disease with the same clinical feature than ataxia-telangiectasia but with a somewhat milder clinical course.
  • 序列相似性Belongs to the MRE11/RAD32 family.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus. Localizes to discrete nuclear foci after treatment with genotoxic agents.
  • Information by UniProt

Recombinant Human Mre11 protein 图像

  • 12.5% SDS-PAGE analysis of Mre11 protein (ab114277). Stained with Coomassie Blue.

Recombinant Human Mre11 protein (ab114277)参考文献

ab114277 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114277.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"