Recombinant人MRC2 protein (ab112386)

概述

  • 产品名称
    Recombinant人MRC2 protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      ASLGMYECDREALNLRWHCRTLGDQLSLLLGARTSNISKPGTLERGDQTR SGQWRIYGSEEDLCALPYHEVYTIQGNSHGKPCTIPFKYDNQWFHGCTST GREDGHLWCA
    • 分子量
      38 kDa including tags
    • 氨基酸
      105 to 214

技术指标

Our Abpromise guarantee covers the use of ab112386 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

    Other

  • 形式
    Liquid
  • 补充说明
    Best to use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

常规信息

  • 别名
    • C-type lectin domain family 13 member E
    • C-type mannose receptor 2
    • CD 280
    • CD280
    • CD280 antigen
    • CLEC 13E
    • CLEC13E
    • ENDO 180
    • ENDO180
    • Endocytic receptor (macrophage mannose receptor family)
    • Endocytic receptor 180
    • FLJ35911
    • KIAA0709
    • Macrophage mannose receptor 2
    • Mannose receptor C type 2
    • MRC 2
    • MRC2
    • MRC2_HUMAN
    • UPAR-associated protein
    • UPARAP
    • Urokinase plasminogen activator receptor associated protein
    • Urokinase receptor associated protein
    • Urokinase receptor-associated protein
    • Urokinase-type plasminogen activator receptor-associated protein
    see all
  • 功能
    May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).
  • 组织特异性
    Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
  • 序列相似性
    Contains 8 C-type lectin domains.
    Contains 1 fibronectin type-II domain.
    Contains 1 ricin B-type lectin domain.
  • 结构域
    C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.
    Fibronectin type-II domain mediates collagen-binding.
    Ricin B-type lectin domain contacts with the second C-type lectin domain.
  • 翻译后修饰
    N-glycosylated.
  • 细胞定位
    Membrane.
  • Information by UniProt

Recombinant Human MRC2 protein 图像

  • 12.5% SDS-PAGE analysis of ab112386. Stained with Coomassie Blue

Recombinant Human MRC2 protein (ab112386)参考文献

ab112386 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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