概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MDPAASSCMRSLQPPAPVWGCLRNPHSEGNGASGLPHYPPTPFSFHQKPD FLATATAAYPDFSASCLAATPHSLPQEEHIFTEQHPAFPQSPNWHFPVSD
    • 分子量
      37 kDa including tags
    • 氨基酸
      1 to 100

相关产品

技术指标

Our Abpromise guarantee covers the use of ab152529 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Homeobox protein MOX-1
    • MEOX1
    • MEOX1_HUMAN
    • Mesenchyme homeo box 1
    • Mesenchyme homeobox 1
    • MOX 1
    • MOX1
    see all
  • 功能
    Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
  • 疾病相关
    Klippel-Feil syndrome 2, autosomal recessive
  • 序列相似性
    Contains 1 homeobox DNA-binding domain.
  • 细胞定位
    Nucleus. Cytoplasm. Localizes predominantly in the nucleus.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab152529 stained with Coomassie Blue.

文献

ab152529 has not yet been referenced specifically in any publications.

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