Recombinant人MOX1 protein (ab114872)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP50221
    • 种属Human
    • 序列PEGSSKARKERTAFTKEQLRELEAEFAHHNYLTRLRRYEIAVNLDLSERQ VKVWFQNRRMKWKRVKGGQPISPNGQDPEDGDSTASPS
    • 分子量36 kDa including tags
    • 氨基酸165 to 252

技术指标

Our Abpromise guarantee covers the use of ab114872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Homeobox protein MOX-1
    • MEOX1
    • MEOX1_HUMAN
    • Mesenchyme homeo box 1
    • Mesenchyme homeobox 1
    • MOX 1
    • MOX1
    see all
  • 功能Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
  • 疾病相关Klippel-Feil syndrome 2, autosomal recessive
  • 序列相似性Contains 1 homeobox DNA-binding domain.
  • 细胞定位Nucleus. Cytoplasm. Localizes predominantly in the nucleus.
  • Information by UniProt

Recombinant Human MOX1 protein 图像

  • 12.5% SDS-PAGE showing ab114872 at approximately 35.79kDa.
    Stained with Coomassie Blue.

Recombinant Human MOX1 protein (ab114872)参考文献

ab114872 has not yet been referenced specifically in any publications.

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