Recombinant人MNK2 protein (ab51441)

概述

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属
      Human
    • 标签
      GST tag N-Terminus

相关产品

技术指标

Our Abpromise guarantee covers the use of ab51441 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Functional Studies

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • G protein coupled receptor kinase 7
    • GPRK7
    • MAP kinase interacting serine threonine kinase
    • MAP kinase interacting serine threonine kinase 2
    • MAP kinase interacting serine threonine protein kinase 2
    • MAP kinase signal integrating kinase 2
    • MAP kinase signal-integrating kinase 2
    • MAP kinase-interacting serine/threonine-protein kinase 2
    • MAPK interacting kinase 2
    • MAPK signal integrating kinase 2
    • Mitogen activated protein kinase interacting serine threonine kinase 2
    • Mknk2
    • MKNK2_HUMAN
    • Mnk2
    • Putative map kinase interacting kinase
    see all
  • 功能
    May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
  • 组织特异性
    Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1.
  • 序列相似性
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • 翻译后修饰
    Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase.
  • Information by UniProt

图片

  • Kinase activity assay - specific activity 95 nmol/min/mg.
  • Recombinant human MNK2 protein (tagged). Molecular weight 74 kDa.

文献

ab51441 has not yet been referenced specifically in any publications.

客户评价及客户问答

ab125635 activity was determined using substrate modified-EIF2S peptide.
ab51441 activity was determined using myelin basic protein.

Thank you for contacting Abcam.
The tag on ab51441 is a ********and so will have a molecular weight of ****.
Please let me if there is anything else I can help you with.

Thank you for your patience in this matter.
I am still waiting to hear back from the supplying lab about the size of the tag. I will contact you as soon as I hear back from them.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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