Recombinant人MMP12 protein (ab80209)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human
    • 序列
      MKFLLILLLQATASGALPLNSSTSLEKNNVLFG
    • 氨基酸
      1 to 33

技术指标

Our Abpromise guarantee covers the use of ab80209 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

  • 复溶
    Redissolve the powder with 1ml sterile water will restore to the original concentration 1mg/ml.

常规信息

  • 别名
    • EC 3.4.24.65
    • HME
    • Macrophage elastase
    • Macrophage metalloelastase
    • Macrophage metaloelastase
    • Matrix metallopeptidase 12 (macrophage elastase)
    • Matrix metalloprotease 12
    • Matrix metalloproteinase-12
    • ME
    • MGC138506
    • MME
    • MMP 12
    • MMP-12
    • Mmp12
    • MMP12_HUMAN
    see all
  • 功能
    May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
  • 组织特异性
    Found in alveolar macrophages but not in peripheral blood monocytes.
  • 序列相似性
    Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • 结构域
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 细胞定位
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

图片

  • 30% SDS PAGE showing ab80209 at approximately 8 kDa.

文献

ab80209 has not yet been referenced specifically in any publications.

客户评价及客户问答

Thank you for contacting us. The question for the MMP12 protein has been forwarded from the customer servicesto us in the technical team.

We do have another MMP12 protein in our catalog, it is the ab80209. http://www.abcam.com/index.html?data...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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