概述

  • 产品名称Recombinant人MMP11 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab92861 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

    Mass Spectrometry

  • 纯度> 90 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: 100mM Imidazole
    Constituents: 0.5M Sodium chloride, 20mM Tris HCl, 1mM Beta mercaptoethanol, pH 8.0

常规信息

  • 别名
    • Matrix Metalloproteinase 11
    • Matrix metalloproteinase-11
    • MMP-11
    • Mmp11
    • MMP11_HUMAN
    • SL 3
    • SL-3
    • SL3
    • ST3
    • STMY3
    • Stromelysin 3
    • Stromelysin III
    • Stromelysin-3
    see all
  • 功能May play an important role in the progression of epithelial malignancies.
  • 组织特异性Specifically expressed in stromal cells of breast carcinomas.
  • 序列相似性Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

Recombinant Human MMP11 protein 图像

  • 10% SDS-PAGE stained with Coomassie Blue.

Recombinant Human MMP11 protein (ab92861)参考文献

This product has been referenced in:
  • Roscilli G  et al. Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients. J Transl Med 12:54 (2014). Read more (PubMed: 24564996) »

See 1 Publication for this product

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