Recombinant人MESDC2 protein (ab104671)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ14696
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMAEGSPGTPDESTPPPRKKKKDIRDYNDAD MARLLEQWEKDDDIEEGDLPEHKRPSAPVDFSKIDPSKPESILKMTKKGK TLMMFVTVSGSPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLR DGSYAWEIKDFLVGQDRCADVTLEGQVYPGKGGGSKEKNKTKQDKGKKKK EGDLKSRSSKEENRAGNKREDL
    • 分子量25 kDa including tags
    • 氨基酸34 to 234
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab104671 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab104671 is purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • BOCA
    • KIAA0081
    • LDLR chaperone MESD
    • MESD
    • MESD_HUMAN
    • MESDC 2
    • mesdc2
    • Mesoderm development candidate 2
    • Mesoderm development protein
    • Renal carcinoma antigen NY REN 61
    • Renal carcinoma antigen NY-REN-61
    see all
  • 功能Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.
  • 序列相似性Belongs to the MESD family.
  • 结构域The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.
    The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.
  • 细胞定位Endoplasmic reticulum.
  • Information by UniProt

Recombinant Human MESDC2 protein 图像

  • 15% SDS-PAGE showing ab104671 at approximately 24.9kDa (3µg).
    Note: Real molecular weight on SDS-PAGE is shifted up compared to predicted molecular weight.

Recombinant Human MESDC2 protein (ab104671)参考文献

ab104671 has not yet been referenced specifically in any publications.

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