Recombinant人MERTK protein (ab72490)

概述

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属
      Human
    • 氨基酸
      578 to 872

相关产品

技术指标

Our Abpromise guarantee covers the use of ab72490 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    The Specific activity of ab72490 was determined to be 1231 nmol/min/mg.
  • 应用

    SDS-PAGE

    Functional Studies

  • 形式
    Liquid
  • 补充说明

    ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • c MER
    • c mer proto oncogene tyrosine kinase
    • c-mer
    • cMER
    • cmer protooncogene tyrosine kinase
    • Eyk
    • MER
    • MER receptor tyrosine kinase
    • MERK
    • MERPEN
    • Mertk
    • MERTK c-mer proto-oncogene tyrosine kinase
    • MERTK_HUMAN
    • MGC133349
    • nmf12
    • Nyk
    • Proto oncogene tyrosine protein kinase MER
    • Proto oncogene tyrosine protein kinase MER precursor
    • Proto-oncogene c-Mer
    • Receptor tyrosine kinase MerTK
    • RP38
    • STK kinase
    • Tyrosine-protein kinase Mer
    see all
  • 功能
    In case of filovirus infection, seems to function as a cell entry factor.
  • 组织特异性
    Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
  • 疾病相关
    Defects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • 序列相似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • 细胞定位
    Membrane.
  • Information by UniProt

图片

  • Kinase Assay demonstrating specific activity of ab72490.
  • SDS-PAGE showing ab72490 at approximately 58kDa.

文献

ab72490 has not yet been referenced specifically in any publications.

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