Recombinant人MelanA protein (ab114312)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ16655
    • 种属Human
    • 序列MPREDAHFIYGYPKKGHGHSYTTAEEAAGIGILTVILGVLLLIGCWYCRR RNGYRALMDKSLHVGTQCALTRRCPQEGFDHRDSKVSLQEKNCEPVVPNA PPAYEKLSAEQSPPPYSP
    • 分子量39 kDa including tags
    • 氨基酸1 to 118

技术指标

Our Abpromise guarantee covers the use of ab114312 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Antigen LB39 AA
    • Antigen LB39-AA
    • Antigen SK29 AA
    • Antigen SK29-AA
    • MAR1_HUMAN
    • MART 1
    • MART-1
    • MART1
    • Melan A
    • Melan A protein
    • Melanoma antigen recognized by T cells 1
    • Melanoma antigen recognized by T-cells 1
    • MLAN A
    • MLANA
    • OTTHUMP00000021036
    • OTTHUMP00000021037
    • OTTHUMP00000021038
    • Protein Melan-A
    see all
  • 功能Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
  • 组织特异性Expression is restricted to melanoma and melanocyte cell lines and retina.
  • 翻译后修饰Acylated.
  • 细胞定位Endoplasmic reticulum membrane. Golgi apparatus. Golgi apparatus > trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
  • Information by UniProt

Recombinant Human MelanA protein 图像

  • SDS-PAGE analysis of ab114312 on a 12.5% gel stained with Coomassie Blue.

Recombinant Human MelanA protein (ab114312)参考文献

ab114312 has not yet been referenced specifically in any publications.

Product Wall

Please note that ab38124 is not a full length protein but a recombinant fragment, corresponding to amino acids 1-150 of Human Melanoma gp100.

As for the stimulation assays, unfortunately we have not tested these proteins in stimulation assays...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"