This product is an active protein and may elicit a biological response in vivo, handle with caution.
MAPK/ERK kinase kinase 2
MEK kinase 2
Mitogen activated protein kinase kinase kinase 2
Mitogen-activated protein kinase kinase kinase 2
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 OPR domain. Contains 1 protein kinase domain.
Cytoplasm. Nucleus. Upon EGF stimulation, translocates into the nucleus.