Recombinant人MEK5 protein (ab114459)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ13163
    • 种属Human
    • 序列MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQ VLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIE PLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSA ELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLD ITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLD VYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELA LGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGESSEPFVHFITQCM RKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQQGPP
    • 分子量75 kDa including tags
    • 氨基酸1 to 448

技术指标

Our Abpromise guarantee covers the use of ab114459 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    ab114459 is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • Dual specificity mitogen activated protein kinase kinase 5
    • Dual specificity mitogen-activated protein kinase kinase 5
    • EC 2.7.12.2
    • HsT17454
    • MAP kinase kinase 5
    • MAP kinase kinase MEK5b
    • MAP2K5
    • MAPK/ERK kinase 5
    • MAPKK 5
    • MAPKK5
    • MEK 5
    • mitogen-activated protein kinase kinase 5
    • MKK5
    • MP2K5_HUMAN
    • PRKMK5
    • Protein kinase, mitogen-activated, kinase 5
    • SAPKK5
    • SKK5
    see all
  • 功能Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.
  • 组织特异性Expressed in many adult tissues. Abundant in heart and skeletal muscle.
  • 序列相似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
    Contains 1 OPR domain.
    Contains 1 protein kinase domain.
  • 结构域Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the OPR domain. This domain also mediates interactions with SQSTM1 and PARD6A.
  • 翻译后修饰Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.
    Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Information by UniProt

Recombinant Human MEK5 protein 图像

  • ab114459 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human MEK5 protein (ab114459)参考文献

ab114459 has not yet been referenced specifically in any publications.

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