Recombinant人MEK3 protein (ab105578)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP46734
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MSKPPAPNPT PPRNLDSRTF ITIGDRNFEV EADDLVTISE LGRGAYGVVE KVRHAQSGTI MAVKRIRATV NSQEQKRLLM DLDINMRTVD CFYTVTFYGA LFREGDVWIC MELMDTSLDK FYRKVLDKNM TIPEDILGEI AVSIVRALEH LHSKLSVIHR DVKPSNVLIN KEGHVKMCDF GISGYLVDSV AKTMDAGCKP YMAPERINPE LNQKGYNVKS DVWSLGITMI EMAILRFPYE SWGTPFQQLK QVVEEPSPQL PADRFSPEFV DFTAQCLRKN PAERMSYLEL MEHPFFTLHK TKKTDIAAFV KEILGEDS
    • 分子量38 kDa including tags
    • 氨基酸20 to 347
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab105578 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab105578 was purified using conventional chromatography.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, pH 8

常规信息

  • 别名
    • AW212142
    • dual specificity mitogen activated protein kinase kinase 3
    • Dual specificity mitogen-activated protein kinase kinase 3
    • MAP kinase kinase 3
    • map2k3
    • MAPK ERK kinase 3
    • MAPK/ERK kinase 3
    • MAPKK 3
    • MAPKK3
    • MEK 3
    • MEK3
    • Mitogen activated protein kinase kinase 3
    • MKK 3
    • MKK3
    • mMKK3b
    • MP2K3_HUMAN
    • PRKMK 3
    • PRKMK3
    • protein kinase, mitogen-activated, kinase 3
    • SAPK kinase 2
    • SAPKK 2
    • SAPKK2
    • Stress activated protein kinase kinase 2
    see all
  • 功能Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
  • 组织特异性Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
  • 疾病相关Note=Defects in MAP2K3 may be involved in colon cancer.
  • 序列相似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated.
    Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity.
    Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Information by UniProt

Recombinant Human MEK3 protein 图像

  • 15% SDS-PAGE analysis of ab105578 (3ug)

Recombinant Human MEK3 protein (ab105578)参考文献

ab105578 has not yet been referenced specifically in any publications.

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