Recombinant人MEK2 protein (ab124543)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP36507
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMGSHMLARRKPVLPALTINPTIAEGPSPTS EGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERIS ELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECN SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIA VLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS FVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELE AIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIV NEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEE VDFAGWLCKTLRLNQPGTPTRTAV
    • 分子量47 kDa including tags
    • 氨基酸1 to 400
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab124543 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab124543 was purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

常规信息

  • 别名
    • Cardiofaciocutaneous syndrome
    • CFC syndrome
    • CFC4
    • Dual specificity mitogen activated protein kinase kinase 2
    • Dual specificity mitogen-activated protein kinase kinase 2
    • ERK activator kinase 2
    • FLJ26075
    • MAP kinase kinase 2
    • map2k2
    • MAPK / ERK kinase 2
    • MAPK/ERK kinase 2
    • MAPKK 2
    • MAPKK2
    • MEK 2
    • MEK2
    • Microtubule associated protein kinase kinase 2
    • Mitogen activated protein kinase kinase 2
    • Mitogen activated protein kinase kinase 2 p45
    • MKK 2
    • MKK2
    • MP2K2_HUMAN
    • OTTHUMP00000165826
    • OTTHUMP00000165827
    • PRKMK 2
    • PRKMK2
    see all
  • 功能Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases.
  • 疾病相关Defects in MAP2K2 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.
  • 序列相似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).
    Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Information by UniProt

Recombinant Human MEK2 protein 图像

  • 15% SDS-PAGE analysis of 3 µg ab124543.

Recombinant Human MEK2 protein (ab124543)参考文献

ab124543 has not yet been referenced specifically in any publications.

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