Recombinant人MDA5 protein (ab112423)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ9BYX4
    • 种属Human
    • 序列HVNMTPEFKELYIVRENKALQKKCADYQINGEIICKCGQAWGTMMVHKGL DLPCLKIRNFVVVFKNNSTKKQYKKWVELPITFPNLDYSECCLFSD
    • 分子量36 kDa including tags
    • 氨基酸928 to 1023

技术指标

Our Abpromise guarantee covers the use of ab112423 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    ELISA

    Western blot

  • 形式Liquid
  • 补充说明Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

常规信息

  • 别名
    • CADM-140 autoantigen
    • Clinically amyopathic dermatomyositis autoantigen 140 kDa
    • DEAD/H (Asp Glu Ala Asp/His) box polypeptide
    • DEAD/H box polypeptide
    • Helicard
    • Helicase with 2 CARD domains
    • Hlcd
    • IDDM 19
    • IDDM19
    • IFIH 1
    • Ifih1
    • IFIH1_HUMAN
    • Interferon induced helicase C domain containing protein 1
    • interferon induced with helicase C domain 1
    • Interferon induced with helicase C domain protein 1
    • Interferon-induced helicase C domain-containing protein 1
    • Interferon-induced with helicase C domain protein 1
    • MDA 5
    • MDA-5
    • Melanoma differentiation associated protein 5
    • Melanoma differentiation-associated gene 5
    • Melanoma differentiation-associated protein 5
    • MGC133047
    • Murabutide down regulated protein
    • Murabutide down-regulated protein
    • RH 116
    • RH116
    • RIG I like receptor 2
    • RLR 2
    • RNA helicase DEAD box protein 116
    • RNA helicase-DEAD box protein 116
    see all
  • 功能RNA helicase that, through its ATP-dependent unwinding of RNA, may function to promote message degradation by specific RNases. Seems to have growth suppressive properties. Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). ATPase activity is specifically induced by dsRNA. Essential for the production of interferons in response to picornaviruses.
  • 组织特异性Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung.
  • 疾病相关Genetic variation in IFIH1 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19) [MIM:610155]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
    Note=IFIH1 is the CADM-140 autoantigen, involved in clinically amyopathic dermatomyositis (CADM). This is a chronic inflammatory disorder that shows typical skin manifestations of dermatomyositis but has no or little evidence of clinical myositis. Anti-CADM-140 antibodies appear to be specific to dermatomyositis, especially CADM. Patients with anti-CADM-140 antibodies frequently develop life-threatening acute progressive interstitial lung disease (ILD).
  • 序列相似性Belongs to the helicase family.
    Contains 2 CARD domains.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • 翻译后修饰During apoptosis, processed into 3 cleavage products. The helicase-containing fragment, once liberated from the CARD domains, translocate from the cytoplasm to the nucleus. The processed protein significantly sensitizes cells to DNA degradation.
  • 细胞定位Cytoplasm. Nucleus. May be found in the nucleus, during apoptosis.
  • Information by UniProt

Recombinant Human MDA5 protein 图像

  • ab112423 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human MDA5 protein (ab112423)参考文献

ab112423 has not yet been referenced specifically in any publications.

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