概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      DLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAE ELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDR KEIPLAKDF
    • 分子量
      38 kDa including tags
    • 氨基酸
      2 to 110

技术指标

Our Abpromise guarantee covers the use of ab152517 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • DNA replication licensing factor MCM6
    • MCG40308
    • Mcm6
    • MCM6 minichromosome maintenance deficient 6
    • MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
    • MCM6_HUMAN
    • Minichromosome maintenance complex component 6
    • Minichromosome maintenance deficient (mis5 S. pombe) 6
    • Minichromosome maintenance deficient 6 homolog
    • Minichromosome maintenance protein 6
    • Mis5
    • MIS5 homolog
    • p105MCM
    see all
  • 功能
    Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
  • 序列相似性
    Belongs to the MCM family.
    Contains 1 MCM domain.
  • 翻译后修饰
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位
    Nucleus. Binds to chromatin during G1 and detach from it during S phase.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab152517 stained with Coomassie Blue.

文献

ab152517 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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