Recombinant人MCFD2 protein (ab92930)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列MASMTGGQQM GRGSHMEEPA ASFSQPGSMG LDKNTVHDQE HIMEHLEGVI NKPEAEMSPQ ELQLHYFKMH DYDGNNLLDG LELSTAITHV HKEEGSEQAP LMSEDELINI IDGVLRDDDK NNDGYIDYAE FAKSLQ

技术指标

Our Abpromise guarantee covers the use of ab92930 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, pH 7.5

常规信息

  • 别名
    • 1810021C21Rik
    • DKFZp686G21263
    • F5F8D
    • LMAN1IP
    • MCFD 2
    • Mcfd2
    • MCFD2_HUMAN
    • Multiple coagulation factor deficiency protein 2
    • Neural stem cell derived neuronal survival protein
    • Neural stem cell-derived neuronal survival protein
    • SDNSF
    see all
  • 功能The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.
  • 疾病相关Defects in MCFD2 are a cause of factor V and factor VIII combined deficiency type 2 (F5F8D2) [MIM:613625]; also known as multiple coagulation factor deficiency 2 (MCFD2). F5F8D2 is a blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.
  • 序列相似性Contains 2 EF-hand domains.
  • 结构域Essentially unstructured in the absence of calcium ions. Requires calcium ions for folding.
  • 细胞定位Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Golgi apparatus.
  • Information by UniProt

Recombinant Human MCFD2 protein 图像

  • 15% SDS-PAGE analysis of 3µg ab92930

Recombinant Human MCFD2 protein (ab92930)参考文献

ab92930 has not yet been referenced specifically in any publications.

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