Recombinant人MARCH8 protein (ab88197)

概述

描述

  • 性质Recombinant
  • 来源Saccharomyces cerevisiae
  • 氨基酸序列
    • 种属Human
    • 序列MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNIS KAGSPPSAS APAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCH CTGSLHFVHQACLQQWIKSS DTRCCELCKYEFIMETKLKPLRKWEKLQ MTSSERRKIMCSVTFHVIAITCVVWSLYVLI DRTAEEIKQGQATGILE WPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVI YVQNCP ETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV

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技术指标

Our Abpromise guarantee covers the use of ab88197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.
    ab88197 was purified using affinity chromatography.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5

常规信息

  • 别名
    • c MIR
    • c-MIR
    • Cellular modulator of immune recognition
    • E3 ubiquitin protein ligase MARCH8
    • E3 ubiquitin-protein ligase MARCH8
    • MARCH 8
    • MARCH VIII
    • MARCH-VIII
    • MARCH8
    • MARH8_HUMAN
    • Membrane associated RING CH protein VIII
    • Membrane associated ring finger (C3HC4) 8
    • Membrane associated RING finger protein 8
    • Membrane-associated RING finger protein 8
    • Membrane-associated RING-CH protein VIII
    • MIR
    • OTTHUMP00000058921
    • RING finger protein 178
    • RNF178
    see all
  • 功能E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
  • 组织特异性Broadly expressed. Present in immature dendritic cells (at protein level).
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 RING-CH-type zinc finger.
  • 结构域The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • 细胞定位Cytoplasmic vesicle membrane. Lysosome membrane. Early endosome membrane.
  • Information by UniProt

Recombinant Human MARCH8 protein (ab88197)参考文献

ab88197 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"