功能E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
组织特异性Broadly expressed. Present in immature dendritic cells (at protein level).
通路Protein modification; protein ubiquitination.
序列相似性Contains 1 RING-CH-type zinc finger.
结构域The RING-CH-type zinc finger domain is required for E3 ligase activity.
细胞定位Cytoplasmic vesicle membrane. Lysosome membrane. Early endosome membrane.