Recombinant人MAPK11 protein (ab125663)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionQ15759
    • 种属Human
    • 分子量71 kDa including tags
    • 氨基酸1 to 364

技术指标

Our Abpromise guarantee covers the use of ab125663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The specific activity of ab125663 was determined to be 780 nmol/min/mg.
  • 应用

    Western blot

    Functional Studies

    SDS-PAGE

  • 纯度> 95 % Densitometry.
    Purity was determined to be >95% by densitometry.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Human p38Beta MAP kinase mRNA complete cds
    • MAP kinase 11
    • MAP kinase p38 beta
    • MAPK 11
    • Mapk11
    • Mitogen activated protein kinase 11
    • Mitogen activated protein kinase p38 2
    • Mitogen activated protein kinase p38 beta
    • Mitogen-activated protein kinase 11
    • Mitogen-activated protein kinase p38 beta
    • MK11_HUMAN
    • p38 2
    • p38-2
    • p38B
    • p38Beta
    • P38BETA2
    • PRKM11
    • Protein kinase mitogen activated 11
    • SAPK2
    • SAPK2B
    • Stress activated protein kinase 2
    • Stress activated protein kinase 2b
    • Stress-activated protein kinase 2
    see all
  • 功能Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2.
  • 组织特异性Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • 结构域The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • 翻译后修饰Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme.
  • Information by UniProt

Recombinant human MAPK11 protein 图像

  • The specific activity of ab125663 was determined to be 780 nmol/min/mg by Kinase Assay.
  • SDS-PAGE analysis of ab125663.

Recombinant human MAPK11 protein (ab125663)参考文献

ab125663 has not yet been referenced specifically in any publications.

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