Recombinant人MAP4K4 protein (ab101775)

概述

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 分子量
      64 kDa including tags
    • 氨基酸
      1 to 328

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技术指标

Our Abpromise guarantee covers the use of ab101775 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    The specific activity of ab101775 was determined to be 54 nmol/min/mg.
  • 应用

    Western blot

    SDS-PAGE

    Functional Studies

  • 纯度
    > 95 % SDS-PAGE.
    Purity was determined to be >95% by densitometry.
  • 形式
    Liquid
  • 补充说明

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • FLH21957
    • FLJ10410
    • FLJ20373
    • FLJ90111
    • Hepatocyte progenitor kinase like/germinal center kinase like kinase
    • HGK
    • HPK/GCK like kinase
    • HPK/GCK like kinase HGK
    • HPK/GCK-like kinase HGK
    • KIAA0687
    • M4K4_HUMAN
    • MAP4K4
    • MAPK/ERK kinase kinase kinase 4
    • MEK kinase kinase 4
    • MEKKK 4
    • MEKKK4
    • Mitogen activated protein kinase kinase kinase kinase 4
    • Mitogen-activated protein kinase kinase kinase kinase 4
    • Nck interacting kinase
    • Nck-interacting kinase
    • NIK
    see all
  • 功能
    Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway.
  • 组织特异性
    Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta.
  • 序列相似性
    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 CNH domain.
    Contains 1 protein kinase domain.
  • 翻译后修饰
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt

图片

  • SDS-PAGE analysis of ab101775.
  • The specific activity of ab101775 was determined to be 54 nmol/min/mg.

文献

ab101775 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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