The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 µg/µl.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Cancer Osaka thyroid oncogene
COT proto oncogene serine/threonine protein kinase
Ewing sarcoma transformant
Mitogen activated protein kinase kinase kinase 8
Mitogen-activated protein kinase kinase kinase 8
Proto oncogene cCot
Serine/threonine protein kinase cot
Serine/threonine-protein kinase cot
Tumor progression locus 2
Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.
Expressed in several normal tissues and human tumor-derived cell lines.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain.
Isoform 1 is activated specifically during the S and G2/M phases of the cell cycle.
Autophosphorylated. Isoform 1 undergoes phosphorylation mainly on Ser residues, and isoform 2 on both Ser and Thr residues.