Recombinant人MAGEA3 protein (ab99958)

概述

  • 产品名称Recombinant人MAGEA3 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP43357
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMGSMPLEQRSQHCKPEEGLEARGEALGLVG AQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNY PLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAELVHFLLLKYRAR EPVTKAEMLGSVVGNWQYFFPVIFSKASSSLQLVFGIELMEVDPIGHLYI FATCLGLSYDGLLGDNQIMPKAGLLIIVLAIIAREGDCAPEEKIWEELSV LEVFEGREDSILGDPKKLLTQHFVQENYLEYRQVPGSDPACYEFLWGPRA LVETSYVKVLHHMVKISGGPHISYPPLHEWVLREGEE
    • 分子量37 kDa including tags
    • 氨基酸1 to 314
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab99958 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab99958 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, 1mM DTT, pH 8.0

常规信息

  • 别名
    • Antigen MZ2 D
    • Antigen MZ2-D
    • Cancer/testis antigen 1.3
    • Cancer/testis antigen family 1 member 3
    • CT1.3
    • HIP8
    • HYPD
    • MAGA3_HUMAN
    • MAGE 3 antigen
    • MAGE-3 antigen
    • MAGE3
    • MAGEA3
    • MAGEA6
    • Melanoma antigen family A 3
    • Melanoma associated antigen 3
    • Melanoma-associated antigen 3
    • MGC1461
    see all
  • 功能Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
  • 组织特异性Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas.
  • 序列相似性Contains 1 MAGE domain.
  • Information by UniProt

Recombinant Human MAGEA3 protein 图像

  • 15% SDS-PAGE showing ab99958 (3µg).

Recombinant Human MAGEA3 protein (ab99958)参考文献

ab99958 has not yet been referenced specifically in any publications.

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